Search results for " diffusion-weighted imaging"

showing 6 items of 6 documents

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subse…

2018

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.…

0301 basic medicineU-PAGE urea-polyacrylamide gel electrophoresisMaleClinical BiochemistryExperimental strokeBiochemistryBrain IschemiaBrain ischemia0302 clinical medicineADC apparent diffusion coefficientApotransferrinDWI diffusion-weighted imagingTANDEM-1 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion clinical trialrHTf rat HTfrATf rat ATflcsh:QH301-705.5chemistry.chemical_classificationNeuronslcsh:R5-920ChemistryTransferrinExtravasationNS21 a medium supplement to grow neuronspDAPK-1 phosphorylated anti-death-associated protein kinase 1NeuroprotectionStrokeWB Western blotFemalemedicine.symptomlcsh:Medicine (General)Research PaperhHTf human HTfPC12 cell line derived from a pheochromocytoma of the rat adrenal medullamedicine.medical_specialtyIron OverloadBBB blood-brain barrierNMDAR N-methyl-D-aspartate receptorDCF dihydrofluoresceinIronWGA wheat germ agglutininHTf holotransferrinTransferrin receptorBrain damageTfR transferrin receptorDeferoxamineNeuroprotectionPI propidium iodide03 medical and health sciencesBrain damageCM conditioned mediumROS reactive oxygen speciesInternal medicine4-HNE 4-hydroxynonenalTf transferrinReceptors TransferrinmedicineFeRhoNoxTM-1 probe to detect Fe2+AnimalsHumansATf apotransferrinCM-H2DCFDA 5-chloromethyl-27-dichlorodihydrofluorescein diacetateMCAO middle cerebral artery occlusionDMT-1 divalent metal transporterB-27 a medium supplement to grow neuronsReactive oxygen speciesNMDA N-methyl-D-aspartateTSAT blood transferrin saturationTransferrin saturationBlood transferrin saturation (TSAT)Organic ChemistryNIR near infraredReactive oxygen species (ROS)medicine.diseasepMCAO permanent middle cerebral artery occlusionRatsPWI perfusion-weighted imaging030104 developmental biologyEndocrinologylcsh:Biology (General)TransferrinDAPK-1 anti-death-associated protein kinaseOGD oxygen/glucose deprivationTTC 235-triphenyl-tetrazolium chlorideLipid PeroxidationMCA middle cerebral arteryApoproteinsReactive Oxygen SpeciesMRI magnetic resonance imagingtMCAO transient middle cerebral artery occlusion030217 neurology & neurosurgeryhATf human ATf
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Physical activity, aerobic fitness, and brain white matter : Their role for executive functions in adolescence

2020

Highlights • Aerobic fitness level, but not physical activity, is related to white matter properties in the brain. • The relation between physical activity and working memory is moderated by fractional anisotropy (FA) of the corpus callosum. • The FA of the corpus callosum and superior corona radiata moderates the relation between aerobic fitness and working memory.

Malephysical activitySpatial memoryDevelopmental psychologyExecutive functionsExecutive Function0302 clinical medicinenuoretCOGNITIVE CONTROLDWI diffusion-weighted imagingFitnessdiffuusiotensorikuvaus315 Sport and fitness sciencesPLASTICITYFA fractional anisotropyChildOriginal ResearchTBSS Tract-Based Spatial Statisticslcsh:QP351-495White matterCognitionExecutive functionsdiffusion tensor imagingexecutive functionsmurrosikäRD radial diffusivityINTEGRITYfitnessfyysinen kuntomedicine.anatomical_structureDiffusion tensor imagingFemalePsychologyaivotRVP rapid visual information processingwhite matterNeurovetenskaperAD axial diffusivityfractional anisotropyfyysinen aktiivisuusMulti-stage fitness testendocrine systemtoiminnanohjaus (psykologia)AdolescentDISTORTION CORRECTIONMVPA moderate-to-vigorous intensity physical activityPhysical activityTFCE threshold-free cluster enhancementWhite matter03 medical and health sciencesWORKING-MEMORY030225 pediatricsmedicineAerobic exerciseHumansExerciseAgedOBJECTIVE MEASURESMD mean diffusivityWorking memoryPhysical activityNeurosciencesPUBERTAL CHANGESvalkea aineCORPUS-CALLOSUMlcsh:Neurophysiology and neuropsychologySWM patial working memoryVOLUMEMICROSTRUCTURECANTAB Cambridge Neuropsychological Automated Test BatteryMRI magnetic resonance imaging030217 neurology & neurosurgeryFractional anisotropy
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Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

2021

[Background and Aims] Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) have been proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH).

0301 basic medicineFIBROSIS NONINVASIVE ASSESSMENTCirrhosisTransient elastographydeMILI0302 clinical medicineMedicineBARIATRIC SURGERY CANDIDATESNon-alcoholic steatohepatitismedicine.diagnostic_testNONALCOHOLIC STEATOHEPATITISFatty liverMagnetic Resonance Imaging3. Good healthArea Under CurveLiver biopsyElasticity Imaging TechniquesNASH-MRI030211 gastroenterology & hepatologyBio-markersRadiologyElastographyDiffusion-weighted imagingLife Sciences & BiomedicineAdultPREDICTS ADVANCED FIBROSISmedicine.medical_specialtyBiomarkers deMILI Diffusion-weighted imaging Magnetic resonance elastography NASH-MRI Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Shear wave elastography Transient elastography AdultArea Under Curve Elasticity Imaging Techniques Humans Magnetic Resonance Imaging Non-alcoholic Fatty Liver Disease ROC Curve fibro-MRI Iron-corrected T1 Liver fibrosisLiver fibrosisCONTROLLED ATTENUATION PARAMETERSTIFFNESS MEASUREMENT03 medical and health sciencesIron-corrected T1HumansFATTY LIVER-DISEASEScience & TechnologyHepatologyGastroenterology & Hepatologybusiness.industryRADIATION FORCE IMPULSEMagnetic resonance imagingmedicine.diseaseCONTROLLED TRANSIENT ELASTOGRAPHYMagnetic resonance elastography030104 developmental biologyROC CurveMagnetic resonance elastographyShear wave elastographyXL PROBEHuman medicinefibro-MRISteatohepatitisbusinessTransient elastographyBiomarkersNon-alcoholic fatty liver diseaseJournal of Hepatology
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Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry

2018

To assess brain-core temperature of end-stage liver disease patients undergoing orthotopic liver transplantation (OLT) using a temperature measurement technique based on the apparent diffusion coefficient of the cerebrospinal fluid in the lateral ventricles. The study group was composed of 19 patients with a model for end-stage liver disease (MELD) score of 23.7 who underwent MR imaging before and after OLT. MR imaging studies were performed with a 1.5T MR scanner. Brain-core temperature (T: °C) was calculated using the following equation from the apparent diffusion coefficient (D) of the cerebrospinal fluid in the lateral ventricles: $$T = {{2256.74} \mathord{\left/ {\vphantom {{2256.74} {…

AdultMaleOrthotopic liver transplantationDWI thermometryThermometryCore temperatureBody Temperature030218 nuclear medicine & medical imagingCohort Studies03 medical and health sciencesLiver disease0302 clinical medicineCerebrospinal fluidmedicineHumansEffective diffusion coefficientRadiology Nuclear Medicine and imagingPostoperative PeriodAgedRetrospective StudiesDWI thermometry; Diffusion-weighted imaging temperature; MR imaging; Orthotopic liver transplantation; Ventricular temperaturesbusiness.industryDiffusion-weighted imaging temperatureSignificant differenceBrainMiddle Agedmedicine.diseaseMr imagingLiver TransplantationDiffusion Magnetic Resonance Imagingsurgical procedures operativeCerebral blood flowCerebrovascular CirculationPreoperative PeriodVentricular temperaturesFemaleOrthotopic liver transplantationNuclear medicinebusiness030217 neurology & neurosurgeryMR imagingJapanese Journal of Radiology
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Unusual MRI findings in an immunocompetent patient with EBV encephalitis: a case report.

2011

Abstract Blackground It is well-known that Epstein-Barr virus (EBV) can affect the central nervous system (CNS). Case presentation Herein the authors report unusual timely Magnetic Resonance Imaging (MRI) brain scan findings in an immunocompetent patient with EBV encephalitis. Diffusion weighted MRI sequence performed during the acute phase of the disease was normal, whereas the Fast Relaxation Fast Spin Echo T2 image showed diffuse signal intensity changes in white matter. The enhancement pattern suggested an inflammatory response restricted to the brain microcirculation. Acyclovir and corticosteroid therapy was administered. After three weeks, all signal intensities returned to normal and…

AdultMalePathologymedicine.medical_specialtySettore MED/07 - Microbiologia E Microbiologia ClinicaEpstein-Barr virus encephalitis MRI Diffusion-weighted imaginglcsh:Medical technologyMononucleosisSettore MED/17 - Malattie InfettiveencephalitisCentral nervous systemCase Reportmedicine.disease_causeWhite matterImmunocompromised HostNeuroimagingmedicineHumansEpstein-Barr virusRadiology Nuclear Medicine and imagingInfectious Mononucleosismedicine.diagnostic_testbusiness.industrySettore MED/37 - NeuroradiologiaMagnetic resonance imagingmedicine.diseaseEpstein–Barr virusMagnetic Resonance Imagingmedicine.anatomical_structurelcsh:R855-855.5Radiology Nuclear Medicine and imagingDiffusion-weighted imagingbusinessEncephalitisDiffusion MRIMRIBMC medical imaging
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Multiparametric 18F-FDG PET-MRI of the breast: are there differences in imaging biomarkers of contralateral healthy tissue between patients with and …

2019

The rationale was to assess whether there are differences in multiparametric 18F-FDG PET/MRI biomarkers of contralateral healthy breast tissue in patients with benign and malignant breast tumors. Methods: In this institutional review board-approved prospective single-institution study, 141 women with imaging abnormalities on mammography or sonography (BI-RADS 4/5) underwent combined 18F-FDG PET/MRI of the breast at 3T with dynamic contrast-enhanced MRI, diffusion-weighted imaging, and the radiotracer 18F-FDG. In all patients, the following imaging biomarkers were recorded for the contralateral (tumor-free) breast: breast parenchymal uptake (BPU) (from 18F-FDG PET), mean apparent diffusion c…

medicine.medical_specialtyImaging biomarkerdiffusion-weighted imagingMalignancy030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerF-18-FDG PET/MRImedicineMammographyEffective diffusion coefficientF-18-FDG PET/MRI breast cancer; dynamic contrast-enhanced MRI diffusion-weighted imaging imaging biomarkerimaging biomarkerRadiology Nuclear Medicine and imagingdynamic contrast-enhanced MRImedicine.diagnostic_testbusiness.industryCancermedicine.disease030220 oncology & carcinogenesisDynamic contrast-enhanced MRIRadiologybusinessDiffusion MRI
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